This can cause serious or life-threatening symptoms.Do not expose your patch or the skin around it to direct heat such as heating pads, electric blankets, heat lamps, saunas, hot tubs, and heated water beds. Do not start, stop, or change the dosage of any medicines without your doctor's approval. tell your doctor if you are breastfeeding. Choose a different place on your skin to apply the next patch. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (such as head injury, tumor, seizures), breathing problems (such as asthma, sleep apnea, chronic obstructive pulmonary disease-COPD), kidney disease, liver disease, mental/mood disorders (such as confusion, depression), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), stomach/intestinal problems (such as blockage, constipation, diarrhea due to infection, paralytic ileus), difficulty urinating (such as due to enlarged prostate), disease of the pancreas (pancreatitis), gallbladder disease. Damage to a patch may allow buprenorphine to pass into your skin too quickly. Do not apply more patches than directed, change them more frequently, or use them for a longer time than prescribed. Do not cover the patch with any other type of bandages or tape. Do not use it later for another condition unless told to do so by your doctor.

Make sure you store the medicine in a safe and secure place to prevent others from getting it. Apply buprenorphine patches exactly as directed. Although not all of these side effects may occur, if they do occur they may need medical attention. It may take 24 hours or longer before you have pain relief from buprenorphine patches. If you need to clean the area before applying the medicine, use only plain water. Do not shave hair since this might cause skin irritation. While using buprenorphine patches, you should talk to your doctor about having a rescue medication called naloxone readily available (e.g., home, office). If your dose is different, do not change it unless your doctor tells you to do so. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). Canada residents can call a provincial poison control center. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location one that is up and away and out of their sight and reach. Buprenorphine belongs to a class of drugs known as opioid analgesics. Talk to your doctor about how you are feeling during your treatment with buprenorphine patches. 1998-2022 Mayo Foundation for Medical Education and Research (MFMER). Apply this medication to the skin as directed by your doctor. What should I know about storage and disposal of this medication? Talk to your doctor about the risks of using buprenorphine patches. Avoid physical activity that might cause you to get very hot. If there is hair on the skin, use scissors to clip the hair as close as possible to the skin. You can also check the DEA web site for locations. Store buprenorphine patches in a safe place so that no one else can use them accidentally or on purpose. Peel off the liner of the disposal unit to reveal the sticky surface. If you leave a patch on for more than 7 days, remove the patch and apply a new patch as soon as you remember. Discuss the risks and benefits with your doctor. If you use buprenorphine transdermal with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Place the sticky side of the used patch on the disposal unit and seal the entire package. If the patch comes off and accidentally sticks to the skin of another person, immediately remove the patch, wash the area with water, and get medical help for them right away. These strengths may cause overdose (even death) if used by a person who has not been regularly taking opioids.Do not use this medication to relieve pain that is mild or that will go away in a few days. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Who should not take Buprenorphine Patch, Transdermal Weekly? Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. The risk for severe breathing problems is higher when you start this medication and after a dose increase, or if you use the wrong dose/strength or misuse the medication (such as chewing or swallowing the patch). Using this medicine while you are pregnant may cause neonatal withdrawal syndrome in your newborn baby. Ask your healthcare professional how you should dispose of any medicine you do not use. Be especially careful to keep buprenorphine patches out of the reach of children. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Use scissors to cut open the pouch containing the buprenorphine patch along the dotted line. Though it helps many people, this medication may sometimes cause addiction. Buprenorphine patches are used to relieve severe pain in people who are expected to need pain medication around the clock for a long time and who cannot be treated with other medications. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. You should make sure that you and your family members, caregivers, or the people who spend time with you know how to recognize an overdose, how to use naloxone, and what to do until emergency medical help arrives. Learn how to properly use, store, and discard the patches. Tell the doctor right away if you notice any symptoms in your newborn baby such as crying that doesn't stop, slow/shallow breathing, irritability, shaking, vomiting, diarrhea, poor feeding, or difficulty gaining weight. Do not use this medicine for mild pain or pain that you only have once in a while or "as needed.". If needed, use water to clean the area. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Press the patch firmly for at least 15 seconds. Do not wear two patches at once unless your doctor has told you that you should. Do not cover it with any other bandage or tape. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Symptoms of overdose may include: slow/shallow breathing, slow heartbeat, coma. Talk to your doctor if you are using marijuana (cannabis). Read the instructions carefully before using the product. However, elderly patients are more likely to have constipation and difficult or painful urination, and have age-related heart, kidney, liver, or lung problems, which may require caution and an adjustment in the dose for patients receiving buprenorphine skin patch to avoid serious side effects. Talk to your doctor about changing your diet or using other medications to prevent or treat constipation while you are using buprenorphine patches. If you are already using an opioid medication, ask your doctor or pharmacist if you should stop or change how you use your other opioid medication. Drug interactions may change how your medications work or increase your risk for serious side effects.

Buprenorphine should not be used to treat mild or moderate pain, short-term pain, or pain that can be controlled by medication that is taken as needed. It is in a class of medications called opiate (narcotic) analgesics. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. If the patch falls off before 7 days, a new patch may be applied to a different skin site. Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, other prescription pain medicine or narcotics, benzodiazepines, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. If you have been using this medicine regularly for several days, do not suddenly stop using it without first checking with your doctor. 12 Medicines That Could Help, List Buprenorphine Patch, Transdermal Weekly side effects by likelihood and severity. May make these conditions worse. Wash your hands with a lot of clear water after applying the medicine. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Weakened physical conditionUse with caution. Used patches may still contain some medication and may be dangerous to children, pets, or adults who have not been prescribed buprenorphine patches. Remove the liner covering the sticky side of the skin patch. If your symptoms return, the person should give you another dose of naloxone. This medication patch may be harmful if chewed or swallowed. Mayo Clinic does not endorse any of the third party products and services advertised. Your doctor may decrease your dose if you experience side effects. If you forget to apply or change a buprenorphine patch, apply the patch as soon as you remember it. Tell your doctor if your pain does not get better or if it gets worse. Your doctor or pharmacist will show you and your family members how to use the medication. Talk to your doctor about using buprenorphine safely. Appropriate studies have not been performed on the relationship of age to the effects of buprenorphine skin patch in the pediatric population. Buprenorphine patches may cause other side effects. Wear the new patch for the period of time prescribed by your doctor (usually 7 days) and then replace it. Be sure to remove your used patch before applying a new patch. Write down the date and time that the patch is applied. Symptoms of an overdose include: drowsiness, extreme dizziness or weakness, irregular, fast or slow, or shallow breathing, pale or blue lips, fingernails, or skin, pinpoint pupils, relaxed and calm, slow heartbeat or breathing, seizures, sleepiness, trouble breathing, or cold, clammy skin. Try not to touch the sticky side of the patch. Using this medication with alcohol or other drugs that can cause drowsiness or breathing problems may cause very serious side effects, including death. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own. Use a Patch Disposal Unit provided to you by the manufacturer to safely dispose of the unneeded or outdated patch(s) in the trash. if you are having surgery, including dental surgery, tell the doctor or dentist that you are using a buprenorphine patch. Using narcotics for a long time can cause severe constipation. Make sure that the entire adhesive surface is attached to your skin, especially around the edges. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. These may be symptoms of a serious condition called serotonin syndrome. Keep all medications away from children and pets. you should know that buprenorphine patches may cause constipation. This drug passes into breast milk and may have undesirable effects on a nursing infant. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. If your doctor tells you to use two patches, you should always change and apply them at the same time. Does Buprenorphine Patch, Transdermal Weekly interact with other drugs you are taking? When handling the skin patch, be careful not to touch the adhesive (sticky) surface with your hand. If you are going to have an MRI test, tell testing personnel that you are using this patch. Do not use this medicine if the pouch seal is broken, or if the patch is cut, damaged, or changed in any way. Ask your pharmacist which type of laxative is right for you. WebMD does not provide medical advice, diagnosis or treatment. This medicine may make you dizzy, drowsy, confused, or disoriented. It may harm an unborn baby. Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. Your doctor may need to change the dosages of your medications and will monitor you carefully. To avoid irritation, apply to a different area each time and do not apply to the same site within 3 weeks. This medication may interfere with certain laboratory tests (including amylase/lipase levels), possibly causing false test results. Do not stop using buprenorphine patches without talking to your doctor. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Talk to your pharmacist about the proper disposal of your medication. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions. If you notice any other effects, check with your healthcare professional. While you are using this medicine, do not use a heating pad, a sunlamp, or a heated water bed, and do not sunbathe, or take long baths or showers in hot water. Do not use soap or other cleansers. Do not apply on burns, cuts, irritated skin, or skin that has been exposed to radiation (x-ray treatment). Remove the patch from the pouch and peel off the protective liner from the back of the patch. You can apply a buprenorphine patch to your upper outer arms, upper chest, upper back, or the side of your chest. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Tell your baby's doctor right away if your baby experiences any of the following symptoms: irritability, hyperactivity, abnormal sleep, high-pitched cry, uncontrollable shaking of a part of the body, vomiting, diarrhea, or failure to gain weight. This can cause an overdose. Seizures, history ofUse with caution. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications, or has had an overdose, or if you have or have ever had depression or another mental illness. You may also need to take a laxative. Be sure to remove the old patch before applying a new patch. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm, American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body. Additional doses may be given every 2 to 3 minutes, if symptoms return before medical help arrives. Anaphylaxis can be life-threatening and requires immediate medical attention. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of buprenorphine skin patch in the elderly. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. You may bathe, shower, or swim while wearing the patch. Properly discard this product when it is expired or no longer needed (see also How to Use section). severe chronic pain with opioid tolerance, severe chronic pain requiring long-term opioid treatment. The dosage is based on your medical condition and response to treatment. If someone accidentally swallows or uses this drug, get medical help right away because fatal breathing problems may occur. For transdermal dosage form (skin patch): AdultsIf you are not using other narcotics regularly, your doctor will determine the correct dose. Ask your doctor or pharmacist about which type of tape should be used. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Do not let anyone else use your medication. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. It may slightly increase the risk of birth defects if used during the first two months of pregnancy. Severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time. Your doctor may start you on a low dose buprenorphine patch and gradually increase your dose, not more often than once every 3 days. The patch is usually applied to the skin once every 7 days. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Tell the doctor right away if your baby develops unusual sleepiness, difficulty feeding, or trouble breathing. This is not a complete list of possible side effects. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. Using too much buprenorphine, or taking too much of another narcotic while using buprenorphine, may cause an overdose. The amount of medicine that you take depends on the strength of the medicine. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. Drinking alcohol or using street drugs during your treatment with buprenorphine transdermal also increases the risk that you will experience these serious, life-threatening side effects. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. AHFS Patient Medication Information. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. If the patch does not stick well or comes loose after it is applied, tape only the edges to your skin with first aid tape. Heat can cause the buprenorphine in the patch to be absorbed into your body faster. Ask your doctor or pharmacist or check the Medication Guide for a list of the ingredients. Use the patch-disposal unit that was provided with your prescription to dispose of the patches. This medication is not for occasional ("as needed") use. This medication has been prescribed for your current condition only. Also, check with your doctor if you get a fever. When you are finished applying the patch, wash your hands with only clear water right away. It works by changing the way the brain and nervous system respond to pain. In people unable to think clearly (such as due to dementia), apply the patch on the upper back to lessen the chance it might be removed or placed in the mouth. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Buprenorphine can cause serious unwanted effects or a fatal overdose if taken by children, pets, or adults who are not used to strong narcotic pain medicines. Avoid taking hot baths and sunbathing. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Alternatively, you may also may fold the sticky sides of a used patch together and flush it down the toilet. Use buprenorphine patches exactly as directed. tell your doctor if you or an immediate family member have or have ever had prolonged QT syndrome (condition that increases the risk of developing an irregular heartbeat that may cause loss of consciousness, or sudden death); or if you have or ever had atrial fibrillation; heart failure; seizures; a head injury, a brain tumor, a stroke or any other condition that caused high pressure inside your skull; biliary tract disease; slowed heartbeat; low blood pressure; low blood levels of potassium; problems urinating; or pancreas, thyroid, heart, kidney, or liver disease. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. During pregnancy, this medication should be used only when clearly needed. In Canada - Call your doctor for medical advice about side effects. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). These may be symptoms of adrenal gland problems. If you accidentally touch the sticky layer to your skin or handle a cut or damaged patch, wash the area well with clear water. Choose a place where the skin is not very oily and is free of scars, cuts, burns, or any other skin irritations. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Transdermal buprenorphine comes as a patch to apply to the skin. Be sure to let your doctor know if this happens. If someone has overdosed, remove the patch if possible. you should know that if you have a fever or if you get very hot after physical activity, the amount of buprenorphine that you receive from the patch may increase and possibly cause an overdosage of medication. If you have any questions, ask your doctor or pharmacist. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Your doctor may decrease your dose if you have sleep apnea (stop breathing for short periods during sleep) while using this medicine. Consult your doctor before breast-feeding.

This medicine comes with a Medication Guide and patient instructions. Make sure laboratory personnel and all your doctors know you use this drug. It belongs to the group of medicines called narcotic analgesics (pain medicines). Do not freeze. Along with its needed effects, a medicine may cause some unwanted effects. Select a condition to view a list of medication options. Call your doctor right away if you have a fever. If you suddenly stop using buprenorphine patches you may have symptoms of withdrawal. Avoid increasing your skin temperature at or near the application site (for example, using products such as heating pads, electric blankets, hot tubs, heat or tanning lamps). The adhesive part of the system contains some buprenorphine, which can be absorbed into your body too fast through the skin of your hand. This drug may rarely cause serious liver disease. Nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, dry mouth, or headache may occur. Your doctor may adjust the dose if needed. Buprenorphine acts on the central nervous system (CNS) to relieve pain. May increase risk for more serious side effects. Your risk for side effects will increase. Buprenorphine may also cause severe, possibly fatal, breathing problems. Tell your doctor right away if you have any serious side effects, including: interrupted breathing during sleep (sleep apnea), mental/mood changes (such as agitation, confusion, hallucinations), difficulty urinating, swelling/blistering at the patch application site, signs of your adrenal glands not working well (such as unusual tiredness, weight loss). (See also Warning section.). Do not use a buprenorphine patch that is cut, damaged, or changed in any way. Buprenorphine is a controlled substance. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Tell your doctor if you are pregnant or plan to become pregnant. you should know that buprenorphine patches may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. Talk to your pharmacist for more details. Should I avoid certain foods while taking Buprenorphine Patch, Transdermal Weekly? Do not apply more patches, apply the patches more often, or use the patches in a different way than prescribed by your doctor. Your doctor will probably decrease your dose gradually. Do not flush the pouch or the protective liner down the toilet. If you feel that the medicine is not working as well, do not use more than your prescribed dose. What should I know regarding pregnancy, nursing and administering Buprenorphine Patch, Transdermal Weekly to children or the elderly? If there is hair on the skin, use scissors to clip the hair as close to the skin as possible. This effect may last for a few days after you stop using this medicine. While using buprenorphine patches, discuss with your health care provider your pain treatment goals, length of treatment, and other ways to manage your pain. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The patch is applied to the skin and left in place for 7 days. The exposed person should then seek medical attention. Be sure you know how to use buprenorphine and what other drugs you should avoid taking with it. you should know that this medication may decrease fertility in men and women. Do not place used patches in the trash without first sealing them in the Patch Disposal Unit. Buprenorphine has a risk for abuse and addiction, which can lead to overdose and death. If your buprenorphine patch is exposed to extreme heat, it may release too much medication into your body at once. If the patch has not been used, take it out of the pouch and remove the liner that covers the sticky side before placing it on the disposal unit. Store it at room temperature and away from excess heat and moisture (not in the bathroom). This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. See also Warning section. All rights reserved. If possible, use a place on the other side of your body. Dry the skin well before applying the patch. Tell your doctor if you have or have ever had breathing difficulties, asthma, chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways), or other lung disease. Leave the new patch in place for 7 days after you apply it. Use this medication on a regular schedule as directed by your doctor, not as needed for sudden (breakthrough) pain. This drug may make you dizzy or drowsy. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. To prevent constipation, eat dietary fiber, drink enough water, and exercise. Keep track of how many patches are left so you will know if any are missing. You may be directed to gradually reduce the amount you are using before stopping treatment completely to lessen the chance of withdrawal side effects (eg, stomach cramps, fever, runny nose, anxiety, or restlessness). The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Tell your doctor right away if your baby has an abnormal sleep pattern, diarrhea, a high-pitched cry, irritability, shakiness or tremors, weight loss, vomiting, or fails to gain weight. Irritation, itching, or redness at the application site may also occur.

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