chromosomal basis of inheritance ppt
d) Trisomic? PracticeLet b+ = gray body and b = black body.
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The unique pattern of inheritance in sex-linked genes. 15.11 in Campbell 9th ed.) Views: 977, By: JenniferDwayne
X InactivationBarr bodiesInactivation is varied, leading to a mosaic of traitse.g.
Scientists think this species may have arisen when an ancestor doubled its chromosome # by errors in mitosis or meiosis. Ep@8+{|f}Psu\Vi-SX?s:F[$=)%VBd EuSv JFIF K K nMSO Palette jJ){R1{bJ{Z))1 1 999 9 9)A A)A)A) A1J)J)J1J1 J1)R1R1 R9 Z9 Z9)ZA1bA bJ1bR9 C Linkage/genetic mapsBased on the idea that the farther apart two genes lie on a chromosome, the more likely a cross over event will occur between them.1 map unit = 1% recombination frequency. Views: 604, By: JenniferDwayne
Explain your answer. What is the probability their 2nd child will have it? 
THE CHROMOSOMAL BASIS OF INHERITANCE CHAPTER 15, Ch. Views: 260, By: JenniferDwayne
Thomas Hunt Morgan Drosophila melanogaster fruit fly
Fast breeding, 4 prs. What are the expected phenotype and genotype ratios?
Why Drosophila?. CHAPTER 15 THE CHROMOSOMAL BASIS OF INHERITANCE .THE CHROMOSOMAL BASIS OF INHERITANCE banding. What are the parents genotypes?
Non-Nuclear DNA Some genes located in organelles
Mitochondria, chloroplasts, plastids
Contain small circular DNA
Mitochondria = maternal inheritance (eggs)
Variegated (striped or spotted) leaves result from mutations in pigment genes in plastids, which generally are inherited from the maternal parent. b`dj+.x76K,>bT|=li=w:W109:~fw4zk?%eh26##ns3%VZx[,Nb?I{);lGEOH5VNx`uuVTa|OD?_j)*%aCrQ*
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Timeline 1866, Ch 15: The Chromosomal Basis of Inheritance, Chapter 15: The Chromosomal Basis of Inheritance, Ch 15: The Chromosomal Basis of Inheritance, Chapter 15: Chromosomal Basis of Inheritance, Chapter 15: The Chromosomal Basis of Inheritance. The Chromosomal Basis for Inheritance. Testcrosses show that the recombination frequency between A and B is 28%, B and C is 5%, and A and C is 12%. Views: 263, By: DrDwayne
What is the linear order of these genes? Determine the sequence of genes along a chromosome based on the following recombination frequencies: A-B, 8 map units; A-C, 19 map units; A-D, 20 map units; B-C, 11 map units; B-D, 28 map units.
What does a frequency of recombination of 50% indicate? 
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(See. The Chromosomal, Chapter 15: The Chromosomal Basis of Inheritance. Views: 594, By: JenniferDwayne
What is the pattern of inheritance of the trait (shaded square/circle) shown in the pedigree? G For exampleThree genes (b, cn, and vg) are found on a single chromosome. 
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b) Triploid? Views: 443, By: JenniferDwayne
c) Monosomic?
Review Questions. Warm up What is a Barr body? d) Trisomic? S4*@DbwMGOmGcwSzywQK@6{lTsjL89ekmFHp=3Ek|TS zmkm*!wii 5-1VxX@oYK1
y{|00H9Z&z 41Pjlh&sQ[apH+jmW$ @{-!wv- |^ j)R-?J>Rd"{Om.c`&a j>oSZ*Z5/v$1_~j( Genetic RecombinationParental typesNon-parental types = recombinant types = recombinantsIf chromosomes independently assort, 50% recombination frequency is expected.Linkage is suspected when recombination is below 50%.Due to crossing-over. chromosomes (XX/XY)
Sex-linked gene: located on X or Y chromosome
Red-eyes = wild-type; white-eyes = mutant
Specific gene carried on specific chromosome, Sex-linked genes Sex-linked gene on X or Y
Females (XX), male (XY)
Eggs = X, sperm = X or Y
Fathers pass X-linked genes to daughters, but not sons
Males express recessive trait on the single X (hemizygous)
Females can be affected or carrier, Transmission of sex-linked recessive traits, Sex-linked disorders Colorblindness
Duchenne muscular dystrophy
Hemophilia. Warm-Up. Thomas Hunt Morgan.
$.' Recombination frequencies are b-cn 9%, cn-vg 9.5%, and b-vg 17%. Let vg+ = normal wings and vg = vestigial wingsWhat is the expected phenotype ratios if a fly heterozygous for both traits is crossed with one that is homozygous recessive for both traits?
",#(7),01444'9=82. Human development Y chromosome required for development of testes
Embryo gonads indifferent at 2 months
SRY gene: sex-determining region of Y
Codes for protein that regulates other genes, Genetic Recombination: production of offspring with new combo of genes from parents If offspring look like parents parental types
If different from parents recombinants, If results do not follow Mendels Law of Independent Assortment, then the genes are probably linked, Linked genes: located on same chromosome and tend to be inherited together during cell division, Crossing over: explains why some linked genes get separated during meiosis the further apart 2 genes on same chromosome, the higher the probability of crossing over and the higher the recombination frequency, Linkage Map: genetic map that is based on % of cross-over events 1 map unit = 1% recombination frequency
Express relative distances along chromosome
50% recombination = far apart on same chromosome or on 2 different chromosomes, Genomic Imprinting Genomic imprinting: phenotypic effect of gene depends on whether from M or F parent
Methylation: silence genes by adding methyl groups to DNA. they can be inherited together if they are located on the same chromosome. > Views: 322. By: JenniferDwayne
Neither Tim nor Rhoda has Duchenne muscular dystrophy (X-linked recessive disorder), but their firstborn son has it. Chapter 15: The Chromosomal Basis of Inheritance 2015-10-28 The Chromosomal Basis of Inheritance 3. The F1 offspring all have normal wings and red eyes. c) Monosomic? Submandibular gland: Surgical Anatomy Tumors Surgery. How many chromosomes are in a human cell that is:
a) Diploid? Down Syndrome = Trisomy 21, Klinefelter Syndrome: 47XYY, 47XXY Nondisjunction. Only four pairs of chromosomes A single mating produces hundreds of offspring - PowerPoint PPT Presentation. Early 1900sColumbia University (New York)Studied genetics of Drosophila melangaster (the common fruit fly), Why Drosophila?Only four pairs of chromosomesA single mating produces hundreds of offspringA new generation can be produced every 2 weeks, Morgan's studies revealedGenes are located on specific chromosomes at specific loci (locations).There are many genes on a single chromosome.Genes can be linked to various degrees (i.e. How genetic imprinting and inheritance of mitochondrial DNA are exceptions to standard Mendelian inheritance. hn\Dv-l9zMdJ)OQN0}qYW7V?2m[H#lS%Ow:>Q#H=6)J[ h(F=7JmUXP>YQiZun /u. Copyright 2016 MedicPresents All rights reserved. What is the pattern of inheritance of the trait (shaded square/circle) shown in the pedigree? can cause genetic disorders. Views: 276, By: JenniferDwayne
), Sex-linkageMorgan discovered that Drosophila eye color was linked to the X chromosome, supporting the chromosome theory of inheritance.X linkage and Y linkage exist. b) Triploid? How many chromosomes are in a human cell that is:
a) Diploid? F #jMzf
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X-Inactivation Barr body = inactive X chromosome; regulate gene dosage in females during embryonic development Cats: allele for fur color is on X
Only female cats can be tortoiseshell or calico.
Microsoft PowerPoint, Microsoft Word and Microsoft Excel are registered trademarks of Microsoft Corporation in the United States and/or other countries. What genotypes and phenotypes do you predict for the offspring? Genetic Testing Reasons for Genetic Tests:
Diagnostic testing (genetic disorders)
Presymptomatic & predictive testing
Carrier testing (before having children)
Pharmacogenetics (medication & dosage)
Prenatal testing
Newborn screening
Preimplantation testing (embryos), Prenatal Testing May be used on a fetus to detect genetic disorders
Amniocentesis: remove amniotic fluid around fetus to culture for karyotype
Chorionic villus sampling: insert narrow tube in cervix to extract sample of placenta with fetal cells for karyotype, Nondisjunction: chromosomes fail to separate properly in Meiosis I or Meiosis II, Karyotyping can detect nondisjunctions. (This is not the same as sex-linkage.).
A colorblind male and a female with normal vision have a son who is colorblind. How alteration of chromosome number or structurally altered chromosomes (deletions, duplications, etc.) Meqq'#=jxEfAqE,mF:wamH o~r^G~ZG[b ^{lgWRRG1 cD&"E!W+kzy m0?Z"TIa|{[]stZ\G#Z>bew0a9_XR@>uO @im5NdpZ.j
=fx R$md3CfsM8Dt`Imj4#~T'W5 When the F1 offspring are crossed with miniature-winged, vermillion-eyed flies, the following offspring resulted:
233 normal wing, red eye
247 miniature wing, vermillion eye
7 normal wing, vermillion eye
13 miniature wing, red eye
What type of conclusions can you draw from this experiment? Early 1900s Columbia University (New York) Studied genetics of Drosophila melangaster (the common fruit fly). All other trademarks are the property of their respective owners.
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Tortoiseshell cats, sweat glands in human females, Note that various systems of sex determination exist.X-YX-OZ-WHaplo-diploid, Homologous chromosomes account for Mendel's Law of Segregation.Non-homologous chromosomes account for Mendel's Law of Independent Assortment, Linked GenesGenes located near each other on the same chromosome tend to be inherited together in genetic crosses.Refers to two or more genes on a single chromosome. PracticeA white-eyed female fruit fly is mated with a wild-type male. Nondisjunction Aneuploidy: incorrect # chromosomes
Monosomy (1 copy) or Trisomy (3 copies)
Polyploidy: 2+ complete sets of chromosomes; 3n or 4n
Rare in animals, frequent in plants
A tetraploid mammal. Colorblindness is a sex-linked recessive trait. What you must know: How the chromosome theory of inheritance connects the physical movement of chromosomes in meiosis to Mendels laws of inheritance. PracticeGenes A, B, and C are located on the same chromosome. The Chromosomal Basis of Inheritance Nov 14, 2012 The Chromosomal Basis of Inheritance Chapter, Lecture07 Chromosomal Basis Inheritance Sv.ppt, Chapter 15~ The Chromosomal Basis of Inheritance, Chromosomal Basis of Inheritance - Biolympiads The Chromosomal Basis of Inheritance . PracticeDetermine the sequence of genes along a chromosome based on the following recombination frequencies: A-C 28%, A-B 8%, A-D 25%, B-C 20%, B-D 33%. Chi-Square Analysis Practice Two true-breeding Drosophila are crossed: a normal-winged, red-eyed female and a miniature-winged, vermillion-eyed male.
15 Warm-Up A white-eyed female fruit-fly is mated with a red-eyed male. How are linkage maps constructed?
(3m] Grade 9 - Chromosomal basis of inheritance, CHAPTER 15 THE CHROMOSOMAL BASIS OF INHERITANCE, 3 Chromosomal Basis of Inheritance .3 Chromosomal Basis of Inheritance follows an X-linked pattern, The Chromosomal Basis of Inheritance - WS AP The Chromosomal Basis of Inheritance. Definitions:
Sex-linked gene
Barr body
SRY gene
Linked genes
Linkage map. Fig. Chromosome theory of inheritance: Genes have specific locations (loci) on chromosomes
Chromosomes segregate and assort independently Chromosomes tagged to reveal a specific gene (yellow).
